Pendred Syndrome

Pendred Syndrome: ASP Health - Patient Assistance Programs

Pendred Syndrome


The Pendred syndrome occurs rarely in children. It is usually associated with hearing loss in both ears (often at birth) and goiter, an enlarged thyroid gland in the neck. Over time, their hearing will usually deteriorate. Goiters typically develop in the teenage years but may appear earlier or later. Pendred syndrome results from a lack of pendrin, a protein that keeps salt levels balanced in the kidney, ear, and thyroid.

Children's thyroids play an important role in growth and development. Even if their thyroid is affected, Pendred syndrome children rarely experience problems with growth and development.

pendred-syndrome

Signs and Symptoms


Pendred syndrome is characterized by the following symptoms:

  • Hearing loss or deafness
  • Goiter
  • Enlarged vestibular aqueduct (inner ear malformation)
  • Hypothyroidism (underactive thyroid gland)
  • Speech impairment
  • Electrolyte/homeostasis imbalance
  • Vertigo (dizzy spells)
  • Kidney dysfunction

Causes


In about 50% of patients with Pendred syndrome, the cause is mutations (changes) in three genes (SLC26A4, FOXI1, or KCNJ10), while in the other half, the cause is unknown. Mutations in SLC26A4 (also known as PDS), which encodes the pendrin protein, are most commonly associated with Pendred syndrome.

A possible 7.5% of congenital hearing loss cases are due to PDS, although the precise prevalence is unknown.

Affected Populations

It affects approximately 2-3 children per 1,000.


pendred-syndrome

Medical care has become increasingly expensive in the US over the past few decades. Many Americans are trying to make a balance with the present situation. With programs like patient assistance, prescription assistance, and co-pay assistance, many pharmaceutical companies and non-profit organizations offer solutions by reducing the medication cost.

What does ASP Health do for patients?


The ASP Health organization is a non-profit organization dedicated to people's health and well-being. Its efforts are aimed at alleviating the physical, mental, emotional, and financial burdens of individuals and families who lack access to healthcare.

ASP Health provides an innovative solution to the rising healthcare costs through patient assistance and co-pay programs.

Patient assistance programs help patients by reducing medical costs. Providing quality care for all your needs is our top priority.

If you still have any queries/doubts or want to enroll, call us at 702-551-5212 or visit our website and apply through our online portal.

It only takes a moment to connect to our support team. Don't you worry. We will take care of everything, whether it is about collecting necessary information or filling up a form.


pendred-syndrome