Liddle Syndrome

Liddle Syndrome: ASP Health- Patient Assistance Programs

Liddle Syndrome

Liddle syndrome is a rare genetic disorder that causes high blood pressure (hypertension) due to abnormal kidney function. A mutation in one of 3 genes (SCNN1A, SCNN1B, and SCNN1G) encodes the epithelial sodium channel (ENaC), causing this disorder. It is monogenic hypertension, meaning that a mutation in just one gene (SCNN1A, SCNN1B, or SCNN1G) is sufficient to cause it.

ASP Health assists patients with prescription drugs and/or medical equipment that are subsidized by pharma companies and governments. We help connect patients with programs that are suitable for them.


Signs and Symptoms

Liddle syndrome has no overt symptoms that distinguish it from other disorders. Individuals with hypertension can also have low potassium levels in their blood (hypokalemia). Symptoms of hypokalemia include muscle weakness or pain, fatigue, constipation, or palpitations. A lack of potassium can also result in metabolic alkalosis, which raises blood pH.


This autosomal dominant disorder is caused by mutations in the epithelial sodium channel genes (SCNN1A, SCNN1B, and SCNN1G). Mutations cause an increase in ENaC activity, sodium and water retention, and hypertension.

The prevalence of Liddle syndrome varies according to estimates. According to a survey of symptoms among veterans with hypertension, 6% met the non-genetic diagnostic criteria for Liddle syndrome (Tapolyai et al. 2010), a much higher prevalence than genetically confirmed cases.

What can ASP Health do for you?

There is an increase in healthcare costs every day. Many find it unable to deal with the out-of-pocket costs of medicines. Different programs are run by pharmaceutical companies, healthcare organizations, and foundations to help the needy. Even if you have insurance, you can enroll in any of the programs if you are eligible. Certain criteria are set for every program.


Why is ASP Health helpful to people?

ASP Health offers services to help patients with their medical needs. Our team at ASP Health simplifies prior authorization and ensures that patients get the most appropriate medication while reducing drug costs. Medications can be purchased at a lower cost through Patient Assistance Programs.

ASP Health programs provide information about assistance programs to patients. We are here to assist you with any form-filling needs, prescription assistance, or medication-taking guidance.

The solution is at your fingertips. All you need to do is dial 405-283-3244. We are there with you if you face any problems. You just take care of your health, the rest we will manage.